Carbamazepine induces bioactivation of cyclophosphamide and thiotepa
نویسندگان
چکیده
منابع مشابه
Peroxidase-mediated bioactivation of hydroxylated metabolites of carbamazepine and phenytoin.
Carbamazepine (CBZ) and phenytoin (PHN) are associated with a relatively high incidence of idiosyncratic drug reactions. Most such reactions are believed to be due to reactive metabolites. The reactions associated with these two drugs are similar, and if a patient has a reaction to one, he or she is at increased risk of having a reaction to the other, suggesting that a similar reactive metaboli...
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We read with interest the recent publications by Ariyoshi et al. (2011) and Raccor et al. (2011). The role of a number of cytochrome P450 (P450) isozymes in the 4-hydroxylation of cyclophosphamide has been debated for several years. There is evidence that both CYP2B6 and CYP2C19 are important in the biotransformation and activation of this prodrug in vitro (Chang et al., 1993, 1997; Huang et al...
متن کاملCytochrome P450 Oxidoreductase Influences CYP2B6 Activity in Cyclophosphamide Bioactivation
INTRODUCTION Cyclophosphamide is commonly used as an important component in conditioning prior to hematopoietic stem cell transplantation, a curative treatment for several hematological diseases. Cyclophosphamide is a prodrug activated mainly by cytochrome P450 2B6 (CYP2B6) in the liver. A high degree of inter- and intra-individual variation in cyclophosphamide kinetics has been reported in sev...
متن کاملRelationship between exposure and toxicity in high-dose chemotherapy with cyclophosphamide, thiotepa and carboplatin.
BACKGROUND High-dose chemotherapy in combination with peripheral blood progenitor cell transplantation is widely used in the treatment of several malignancies. The use of high-dose chemotherapy can be complicated by the occurrence of severe and sometimes life threatening toxicity. A wide interpatient variability in toxicity is encountered, which may be caused by variability in the pharmacokinet...
متن کاملATG vs thiotepa with busulfan and cyclophosphamide in matched-related bone marrow transplantation for thalassemia.
Matched-related bone marrow transplantation (BMT) may cure >80% of low-risk children with severe thalassemia (ST). Very long-term follow-up studies have shown how the standard busulfan-cyclophosphamide (BuCy) regimen may be associated with normalization of health-related quality of life, no second malignancies in the absence of chronic graft-versus-host disease, and fertility preservation in ma...
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ژورنال
عنوان ژورنال: Cancer Chemotherapy and Pharmacology
سال: 2008
ISSN: 0344-5704,1432-0843
DOI: 10.1007/s00280-008-0758-y